BackgroundResponsive neurostimulation has been utilized as a treatment for intractable epilepsy. The RNS System delivers stimulation in response to detected abnormal activity, via leads covering the seizure foci, in response to detections of predefined epileptiform activity with the goal of decreasing seizure frequency and severity. While thalamic leads are often implanted in combination with cortical strip leads, implantation and stimulation with bilateral thalamic leads alone is less common, and the ability to detect electrographic seizures using RNS System thalamic leads is (...) uncertain.ObjectiveThe present study retrospectively evaluated fourteen patients with RNS System depth leads implanted in the thalamus, with or without concomitant implantation of cortical strip leads, to determine the ability to detect electrographic seizures in the thalamus. Detailed patient presentations and lead trajectories were reviewed alongside electroencephalographic analyses.ResultsAnterior nucleus thalamic leads, whether bilateral or unilateral and combined with a cortical strip lead, successfully detected and terminated epileptiform activity, as demonstrated by Cases 2 and 3. Similarly, bilateral centromedian thalamic leads or a combination of one centromedian thalamic alongside a cortical strip lead also demonstrated the ability to detect electrographic seizures as seen in Cases 6 and 9. Bilateral pulvinar leads likewise produced reliable seizure detection in Patient 14. Detections of electrographic seizures in thalamic nuclei did not appear to be affected by whether the patient was pediatric or adult at the time of RNS System implantation. Sole thalamic leads paralleled the combination of thalamic and cortical strip leads in terms of preventing the propagation of electrographic seizures.ConclusionThalamic nuclei present a promising target for detection and stimulation via the RNS System for seizures with multifocal or generalized onsets. These areas provide a modifiable, reversible therapeutic option for patients who are not candidates for surgical resection or ablation. (shrink)

The digital teaching of medieval, and especially auxiliary, scientific skills has been going on for more than a decade. Nevertheless, the breadth and depth of the auxiliary sciences is making them difficult to present in their entirety. With ‘Ad fontes’, basic knowledge of skills needed to study the Middle Ages is imparted through interactive exercises. The e-learning platform was completely revised in 2018, allowing new technical possibilities to be realised while maintaining the strengths of its intuitive exercises. Additionally, crowdsourcing enterprises (...) prove extremely valuable in the application of knowledge. After all, it is only possible to bring together knowledge of a particular field if collaborations are established across individual institutions and researchers. (shrink)

Hate is widespread online, hits everyone, and carries negative consequences. Crowd moderation—user-assisted moderation through, e. g., reporting or counter-speech—is heralded as a potential remedy. We explore this potential by linking insights on online bystander interventions to the analogy of crowd moderation as a (lost) public good. We argue that the distribution of costs and benefits of engaging in crowd moderation forecasts a collective action problem. If the individual crowd member has limited incentive to react when witnessing hate, crowd moderation is (...) unlikely to manifest. We explore this argument empirically, investigating several preregistered hypotheses about the distribution of individual-level costs and benefits of response options to online hate using a large, nationally representative survey of Danish social media users (N = 24,996). In line with expectations, we find that bystander reactions, especially costly reactions, are rare. Furthermore, we find a positive correlation between exposure to online hate and withdrawal motivations, and a negative (n-shaped) correlation with bystander reactions. (shrink)

Radical ecology typically brings to mind media images of ecological activists standing before loggers' saws, staging anti-nuclear marches, and confronting polluters on the high seas. Yet for more than twenty years, the activities of organizations such as the Greens and Earth First! have been influenced by a diverse, less-publicized group of radical ecological philosophers. It is their work—the philosophical underpinnings of the radical ecological movement—that is the subject of _Contesting Earth's Future_. The book offers a much-needed, balanced appraisal of radical (...) ecology's principles, goals, and limitations. Michael Zimmerman critically examines the movement's three major branches—deep ecology, social ecology, and ecofeminism. He also situates radical ecology within the complex cultural and political terrain of the late twentieth century, showing its relation to Martin Heidegger's anti-technological thought, 1960s counterculturalism, and contemporary theories of poststructuralism and postmodernity. An early and influential ecological thinker, Zimmerman is uniquely qualified to provide a broad overview of radical environmentalism and delineate its various schools of thought. He clearly describes their defining arguments and internecine disputes, among them the charge that deep ecology is an anti-modern, proto-fascist ideology. Reflecting both the movement's promise and its dangers, this book is essential reading for all those concerned with the worldwide ecological crisis. (shrink)

Drawing upon selected literature from the United Kingdom, Denmark, and Canada we examine how Foucault's concepts of ‘episteme’, ‘rupture’ ‘parrhesia’ ‘care of the self’, and ‘problemitization’ have been applied to particular contexts of leadership development, pedagogy, nursing knowledge, and the relationship between caring and politics. Our aims are threefold: to give examples of how selected Foucauldian concepts have been taken up in practice; to clarify how we are positioned today as nurses; and to invite more nurses to engage critically with (...) historical inquiry and to engage in deep philosophical reflection about their relationship with nursing. We begin by examining the conditions and circumstances of Foucault's life, and conclude by posing the question in our subtitle to stimulate debate about the philosophical relevance of Foucauldian scholarship to nursing. (shrink)

In a series of essays David Gauthier develops a two-tier pragmatic theory of practical rationality and argues, within that theory, for a distinctive account of the rationality of following through with prior assurances or threats. His discussion suggests that certain kinds of temporally extended agency play a special role in one’s temporally extended life going well. I argue that a related idea about diachronic self-governance puts us in a position to explain a sense in which an accepted deliberative standard can (...) be self-reinforcing. And this gives us resources to adjust Gauthier’s theory in response to a basic challenge. (shrink)

I argue that the many worlds explanation of quantum computation is not licensed by, and in fact is conceptually inferior to, the many worlds interpretation of quantum mechanics from which it is derived. I argue that the many worlds explanation of quantum computation is incompatible with the recently developed cluster state model of quantum computation. Based on these considerations I conclude that we should reject the many worlds explanation of quantum computation.

Daniel, Michael E Review(s) of: Australians and the Christian god: An historical study, by Hugh Jackson, (Preston: Mosaic Press, 2013), pp.209, $37.95.

Daniel, Michael E Review of: Saints, sacrilege and sedition: Religion and conflict in the Tudor reformations, by Eamon Duffy, pp. 253, paperback, $27.99.

This is a reply to discussions by David Copp, Tamar Schapiro, and Sergio Tenenbaum of Michael E. Bratman, Shared Agency: A Planning Theory of Acting Together.

Physical theories often characterize their observables with real number precision. Many non-fundamental theories do so needlessly: they are more precise than they need to be to capture the physical matters of fact about their observables. A natural expectation is that a truly fundamental theory will require its full precision in order to exhaustively capture all of the fundamental physical matters of fact. I argue against this expectation and I show that we do not have good reason to expect that the (...) standard of precision set by successful theories, or even by a truly fundamental theory, will match the granularity of the physical facts. (shrink)

Controversy and activism have long been linked to the subject of primate research. Even in the midst of raging ethical debates surrounding fertility treatments, genetically modified foods and stem-cell research, there has been no reduction in the campaigns of activists worldwide. Plying their trade of intimidation aimed at ending biomedical experimentation in all animals, they have succeeded in creating an environment where research institutions, often painted as guilty until proven innocent, have avoided addressing the issue for fear of becoming targets. (...) One area of intense debate is the use of primates in stroke research. Despite the fact that stroke kills more people each year than AIDS and malaria, and less than 5% of patients are candidates for current therapies, there is significant opposition to primate stroke research. A balanced examination of the ethics of primate stroke research is thus of broad interest to all areas of biomedical research. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:78 Discussion c:\users\kenneth\documents\type3401\rj 3401 193 red.docx 2014-05-14 8:54 PM MORE WIT IN PM Michael E. Berumen 37155 Dickerson Run Windsor, co 80550, usa [email protected] eldom does one find a piece by Bertrand Russell without a morsel of humour or wryness. Sometimes the Russellian wit is obvious. Other times it is more subtle, maybe even requiring a second look just to be sure. Headlong into some of his most (...) technical and difficult works, a delightful bon mot might suddenly punctuate the philosophical solemnity. One doesn’t ordinarily think of Principia Mathematica as a sourcebook for Russellian waggishness, but it is there, to be sure—albeit one will negotiate many pages of symbols and scant prose before finding a specimen. Perhaps the best-known witticism amongst cognoscenti is, after having proved 1 + 1 = 2 (PM ∗110.643, 2: 83), the authors observe, “The above proposition is occasionally useful.” The most complete directory for these jewels that I know is by Kenneth Blackwell.1 I thought it unlikely another would be found, so imagine my surprise when, after having dusted off my seldom-used Volume 3 to look something up, I came across a droll nugget that (to the best of my knowledge) has not been highlighted before. Something tells me Russell was biting down on his pipe stem and had a twinkle in his eye when he (I assume Russell, but they, anyway) wrote in the summary of Section A of Part vi, “Quantity”: Great difficulties are caused, in this section, by the existence-theorems and the question of types. These difficulties disappear if the axiom of infinity is assumed, but it seems improper to make the theory of (say) 2/3 depend upon the assumption that the number of objects in the universe is not finite. (PM 3: 234; italics mine) “Improper” indeed, the erstwhile Victorian says! By way of explanation, he goes on to say, We have, accordingly, taken pains not to make this assumption, except where, as in the theory of real numbers, it is really essential, and not merely convenient. Even that has a bit of Russellian sarcasm. So, accept the challenge and find another. In the meantime, take comfort in the knowledge that the sometimes controversial Axiom of Infinity is an unnecessary assumption in mixing one part soda and two parts Red Hackle. 1 “The Wit and Humour of Principia Mathematica”, Russell 31 (2011): 151–60. S... (shrink)

The Strange Situation procedure was developed by Ainsworth two decades agoas a means of assessing the security of infant-parent attachment. Users of the procedureclaim that it provides a way of determining whether the infant has developed species-appropriate adaptive behavior as a result of rearing in an evolutionary appropriate context, characterized by a sensitively responsive parent. Only when the parent behaves in the sensitive, species-appropriate fashion is the baby said to behave in the adaptive or secure fashion. Furthermore, when infants are (...) observed repeatedly in the Strange Situation,the pattern of behavior is said to be highly similar, and this pattern is said to predict the infants' future behavior in a diverse array of contexts. After an exhaustive review of the literature, it is shown that these popular claims are empirically unsupported in their strong form, and that the interpretations in terms of biological adaptationare misguided. There is little reliable evidence about the specific dimensions of parental behavior that affect Strange Situation behavior, although there does appear to be some relationship between these constructs. Temporal stability in security of attachment ishigh only when there is stability in family and caretaking circumstances. Likewise, patterns of Strange Situation behavior only have substantial predictive validity in similarly stable families. Implications for future research and theorizing — particularly as they relate to the use of evolutionary biology in psychological theory — are discussed. (shrink)

Ray Kurzweil and others have posited that the confluence of nanotechnology, artificial intelligence, robotics, and genetic engineering will soon produce posthuman beings that will far surpass us in power and intelligence. Just as black holes constitute a ldquo;singularityrdquo; from which no information can escape, posthumans will constitute a ldquo;singularity:rdquo; whose aims and capacities lie beyond our ken. I argue that technological posthumanists, whether wittingly or unwittingly, draw upon the long-standing Christian discourse of ldquo;theosis,rdquo; according to which humans are capable of (...) being God or god-like. From St. Paul and Luther to Hegel and Kurzweil, the idea of human self-deification plays a prominent role. Hegel in particular emphasizes that God becomes wholly actualized only in the process by which humanity achieves absolute consciousness. Kurzweil agrees that God becomes fully actual only through historical processes that illuminate and thus transform the entire universe. The difference is that for Kurzweil and many other posthumanists, our offspringmdash;the posthumansmdash;will carry out this extraordinary process. What will happen to Home sapiens in the meantime is a daunting question. (shrink)

Daniel, Michael E Review of: Martin Griver unearthed, by Odhran O'Brien, Strathfield, NSW: St Pauls, 2014, pp. 261, hardback, $39.95; paperback, $35.95.

A study of Chrisoula Andreou’s Choosing Well. Andreou defends “a revisionary way of understanding instrumental rationality,” one that contrasts with “standard conceptions of instrumental rationality” that are characteristic of orthodox decision theory. I applaud Andreou’s revisionary efforts but explore whether they lead to a yet further revision that appeals to norms of plan rationality.

Daniel, Michael E Review(s) of: Benedict XVI: A guide for the perplexed, by Tracey Rowland, London: T and T Clark International, 2010, pp.160, $29.95.

J. Baird Callicott seeks to resolve the problem of the intrinsic value of nature by utilizing a nondualistic paradigm derived from quantum theory. His approach is twofold. According to his less radical approach, quantum theory shows that properties once considered to be “primary” and “objective” are in fact the products of interactions between observer and observed. Values are also the products of such interactions. According to his more radical approach, quantum theory’s doctrine of internal relations is the model for the (...) idea that everything is intrinsically valuable because the “I” is intrinsically valuable and related to everything else. I argue that humanity’s treatment of nature will become respectful only as humanity’s awareness evolves toward nondualism, and that such nondualistic awareness will not be produced by changes in scientific theory alone. Nevertheless, as Callicott suggests, such changes may be harbingers of evolutionary trends in human awareness. I conclude with a sketch of how nondualism, especially in its panentheistic version, provides the basis for environmental ethics. (shrink)

The experience of free will has causal consequences, albeit not immediate ones. Although Wegner recognizes this, his model failed to incorporate this causal link. Is this experience central to “what makes us human”? A broad acceptance of Wegner's claim that free will is illusory has significant societal and religious consequences, therefore the threshold of evidence needs to be correspondingly high.

Integral Ecology uses multiple perspectives to analyze environmental problems. Four of Integral Ecology's major analytical perspectives (known as the quadrants) correspond to the four divisions of the liberal arts and sciences: fine arts, natural science, social science, and humanities. Integral Ecology also utilizes the analytical perspective provided by the idea of cultural moral development. This perspective helps to reveal how stakeholders at different developmental stages disclose a phenomenon, in this case, a tropical forest that loggers propose to clear-cut. Integral Ecology (...) takes into account all pertinent perspectives, in order to arrive at the best possible solution to environmental problems and conflicts. (shrink)